Tizanidine: instructions for use, indications, price

 

Pharmacological properties

"Tizanidine" is included in the group of centrally acting muscle relaxants. The active ingredient of the drug is tizanidine (tizanidine hydrochloride), the content of which in 1 tablet is 2 or 4 g.

The tool stimulates the presynaptic alpha-2-adrenergic receptors located in the spinal cord. In addition, it inhibits the release of mediator amino acids that stimulate receptors for N-methyl-D-aspartate (NMDA receptors), which results in the inhibition of polysynaptic excitation transmission in the spinal cord.

This leads to a decrease in muscle tone, as well as a decrease in muscle stiffness during passive movements and an increase in the strength of skeletal muscle contractions, a decrease in spasms, and clonic convulsions.

Indications

The use of "Tizanidine" is indicated for painful spasms of muscles, spasticity of skeletal muscles associated with multiple sclerosis, diseases, damage to the spinal cord.

Contraindications

Contraindications to the appointment of "Tizanidine":

  • severe disruption of the liver;
  • administration of alpha-2-adrenomimetics, Fluvoxamine, Ciprofloxacin, and other inhibitors of the CYP1A2 isoenzyme;
  • periods of pregnancy and lactation;
  • age up to 18 years;
  • identified hypersensitivity to the drug.

With caution, the medicine is prescribed in the following cases:

  • hypertension;
  • abnormal liver function (moderate);
  • renal failure;
  • bradycardia;
  • simultaneous administration of “Ticlopidine”, “Norfloxacin”, “Digoxin”, “Cimetidine”, diuretics, beta-blockers, oral contraceptives, antiarrhythmic, antihypertensive, sedatives;
  • age from 65 years.

Instruction

Dosage "Tizanidina" must pick up the attending physician. The abstract indicates the recommended amount - 2 mg 3 p. / Day. In this case, the risk of adverse reactions is minimal. If muscle cramps are painful, a single amount is increased to 4 mg. If the case is severe, they may prescribe an additional dose of 2 or 4 mg (at bedtime).

Dosage for the treatment of skeletal muscle spasticity caused by neurological diseases is selected individually.Usually the optimal effect is achieved if you take 12-24 mg per day, divided into 3-4 doses. The maximum daily dose at the beginning of therapy should not exceed 6 mg in 3 doses. In the future, it can be increased by 2-4 mg (every 3-7 days), not exceeding the daily amount of 36 mg.

Cancel "Tizanidina" is carried out gradually. According to reviews, this reduces the likelihood of increased blood pressure and the development of tachycardia (rebound phenomenon).

Side effects

The drug may cause the following side effects:

  • gastrointestinal disorders, nausea;
  • decrease in blood pressure, bradycardia;
  • drowsiness, dizziness;
  • muscle weakness;
  • allergy;
  • sleep disorders, insomnia, hallucinations;
  • increased fatigue.


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